Unexpected Roles of Soluble α-Synuclein Post-translational Modifications in Pathological α-Synuclein Amplification

Author(s): Shujing Zhang, Chao Peng, Yuhan Sun

This short review summarizes the effect of soluble α-Synuclein (α-Syn) post-translational modifications (PTMs) on pathological α-Syn amplification. Most previous studies of pathological α-Syn transmission and amplification focused on pathological α-Syn seeds themselves. Our recent study showed, for the first time, how phosphorylation and acetylation of soluble and nonpathological α-Syn affect the amplification of pathological α-Syn in a modification site- and conformation-specific manner. Also, a series of novel modifications on soluble α-Syn have been discovered for future research. Moreover, we proposed the importance of the different roles of PTMs during the different stages of pathology development.

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